Jan Nolta Lab in the UC Davis Medical Center
Institute for Regenerative Cures - 2016
The fields of stem cells, immunotherapy, gene therapy and regenerative medicine are poised to change the face of healthcare. Immunotherapy is giving terminal cancer patients a second chance at life, gene therapy can cure rare diseases, and living stem cells are beginning to be prescribed for certain indications. This changes the fields of medicine, nursing, and pharmacy, since the new generations of healthcare students will need to learn how to handle drugs that are not pills or liquids in a vial, but rather are living biological medicines. The new medicine is performed in large teams of experts with different expertise and backgrounds, including those with cell biology and manufacturing knowledge, in addition to experts in medicine, surgery, imaging, monitoring, outcomes, health technology and statistical analysis. At UC Davis we are committed to training the science and healthcare work force of the future, and to continuing to improve and deliver these novel cutting edge therapies that can offer cures rather than remedies or palliative care for patients who currently have limited options.
Social media enhances teamwork by allowing closer interaction between scientists, patients and patient advocates, MDs, Veterinarians, technology experts, foundations, philanthropists, funding agencies, industry partners, and students at all levels, including interested members of the public. The common passion to treat a specific disease or disorder unites these interesting multifaceted teams, and each member brings a unique perspective to the group. It is important for members of these broad and committed groups to remember to always seek evidence-based solutions for developing novel treatments that have the best chance of impacting the disorder that they hope to cure. Publication of peer-reviewed “Proof-of-Concept” data in reputable journals with relatively high impact factor should accompany claims of efficacy.
The University of California Davis Stem Cell Program brings together interested people from different backgrounds to make important advances in the field of regenerative medicine in twenty different disease teams/focus areas. Through the hub at the 109,000 SF Institute for Regenerative Cures building, these teams share knowledge, students, equipment, and ideas, to best leverage skills to develop novel life-saving therapies.
We have a large number of trainees of all ages who work with us at the IRC. The layout of the teams who have hubs in the Shared Transllational Lab is shown below. The majority of these teams are directed by Physician-scientists workign with Dr. Nolta, and the trainees are housed here:
To make a tax-free donation online please choose "stem cell program" from the drop-down menu at:
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Liver team: working on bioengineering of liver from induced pluripotent stem cell self-assembling organoids. Left to right: Dane Coleal-Bergum, Aja Harding, Ping Zhou, Ph.D.
UC Davis Huntington's disease team- 2015 photo. This team is led by Dr. VIcki Wheelock, who runs the UC Davis Huntington's Disease Clinic, which is recognized as a Center of Excellence
UC Davis Juvenile HD gene editing team. Kyle FInk, Ph.D. (back, center) is the leader for this team and they are working extremely hard to make a difference for kids with the devastating disease JHD. Please see www.jhdkids.com for disease info, stories about each child, and ways to donate to their bucket lists.
Dr. Diana Farmer, Chair, Department of Surgery (center) and her team do incredible work in fetal surgery. They help babies with spina bifida while they are still in the womb. They are developing a novel stem cell therapy for spina bifida in collaboration with our team at the IRC.
Wound healing and revascularization team led by Dr. Fernando Fierro, Ph.D.
Left to right: Andrew Cicchetto, Heather Stewart (Dahlenburg), Fernando Fierro, Julie Beegle, Nataly Magner, Stefanos Kalomoiris
The Swallowing DIsorders team, led by Dr. Peter Belafsky (center, white shirt) is working to make a difference for patients with swallowing disorders. The team received seed funding from the National Foundation for Swallowing Disorders (NFSOD).
Dr. Stefan Kalomoiris, pictured below (black shirt), with Dr. Belafsky's Fellow Derrick Randall (white shirt) is the Denny and Jeanene Dickenson's fellow working on the project to develop the product MuscleRegenix to enhance tongue volume and function for swallowing disorders and to treat other injuries or disease that have muscle damage/ loss.
Please see our new publication and mesenchymal stem cell video:
Human Myoblast and Mesenchymal Stem Cell Interactions Visualized by Videomicroscopy.
Hum Gene Ther Methods. 2015 Dec;26(6):193-6. doi: 10.1089/hgtb.2015.100. Epub 2015 Nov 6.
Mesenchymal stem cells (red) communicate with myoblasts (green) through cell-to-cell communication using micropoarticles, tunneling nanotubules and nanobridges. The video shows red particles coming from the MSCs, which we also call the "paramedics of the body" and being absorbed into the green muscle-building myoblasts.
The exosome team, led by Dr. Johnathon Anderson (light blue shirt), is studying the use of exosomes, a sophisticated method of cell-to-cell communication, to treat vascular diseases including critical limb ischemia/PAD, heart disease and stroke.
Gerhard Bauer- Director of the UC Davis Good Manufacturing Practices Facility, Jan Nolta, and Geralyn Annett - Stem Cell Program Manager- sending a pre-IND package for the HD therapy to the FDA from Jan's office.
From left to right: Matt Lindsey, Suzanne Pontow, Karen Pepper, Cheryl Walker, Fernando Fierro, Peny Riggs, Yunjoon Jung, Nancy Burford, Stefan Kalomoiris, Karen O'Donnell, Ping Zhou, Jeanie Liu, Bill Gruenloh, Louisa Wirthlin, Whitney Cary, Gaela-Marie Mitchell, Nic Cu, Geralyn Annett
Gerhard Bauer and Joe Anderson- HIV team
Mark Grundmann - Webmaster, media, technical consultant, transportation logistics, monitoring current events, hosting events, computer technology, time management specialtist, protection services, telecommunications and electronic devices, philanthropist and entrepeneur. (Volunteer)
Lab Members picture 2008
Lab members picture 2009-taken at our Monday morning lab meeting August '09
Photo of the team members working together in our shared translational laboratory in the new UC Davis/CIRM Institute for Regenerative Cures.
These scientists and physicians work in "bench to bedside" teams to enable clinical trials.
Nolta lab members and Stem Cell Program Core Directors at the IRC Grand Opening
Nolta lab plus CIRM students and stem cell program volunteers 2009
still under construction!
More students/lab members to add.....